Human-on-a-chip control system

Control System for Human-on-a-Chip

This technology utilizes multiple magnetic field coils to apply independent external magnetic fields to the entire or local areas of a human-on-a-chip, enabling the actuation (fluid flow control) and precise positioning (organ docking) of microrobots injected inside.

Existing human-on-a-chip systems rely on constant flow control using external pumps, which makes local precision control difficult and results in complex structural designs and low efficiency when docking artificial or micro-organs at specific locations.

This technology uses independently arranged magnetic field coil units around the chip network to perform local/global magnetic field steering and intensity modulation. By controlling the rotational speed and direction of helical or propeller-type microrobots, it simulates fluid flow or precisely docks microrobots at target locations. Applicable to industrial robots and automation systems, it improves the efficiency of micro-organ positioning and fluid flow within the network, enabling the creation of environments that closely mimic the human body.

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Key Features:

• Local area magnetic field coil unit that applies an external magnetic field locally to areas of the biological organ model and network.
• The magnetic field coil device includes a global area magnetic field coil unit that applies an external magnetic field across the entire chip area.
• The global area magnetic field coil unit controls the positions of multiple microrobots simultaneously to collectively place them at pre-determined micro-organ locations within the human-on-a-chip control system.
• A network connecting the micro-organs that constitute the biological organ model.

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This invention was developed with support from the Ministry of Science, ICT and Future Planning for the development of 3D precision magnetic microstructures and cell/drug delivery-based technology.