This technology is a capsule structure designed for multi-site biological material sampling. It induces active sample adsorption at target locations by sequentially dissolving a pH-responsive outer protective layer and a temperature-controlled inner protective layer (via a heating layer) to expose a polymer layer. It includes a position and orientation control mechanism based on an external magnetic field using a magnetic body housed within the main unit.
Conventional sampling devices rely solely on passive movement via intestinal peristalsis, and their sampling methods depend exclusively on specific pH environments, making precise selective sampling or multi-site discrete sampling impossible.
This technology implements a structure that allows users to sequentially activate specific sampling modules at desired times and locations by applying inner protective layers with different melting points to each module and independently controlling the heating layer of each module through external signal application. Applicable to surgical robots, interventional systems, and medical automation, it provides a non-invasive method, reduces costs, and improves the ability to collect biological materials from within the digestive tract by enabling access to multiple locations within the gastrointestinal tract.
This invention was developed through support for the development of a micro-carrier-based active precision delivery medical device for multi-departmental knee cartilage regeneration.
WO2025-018529A1
