This technology increases intracellular phycobiliprotein and thylakoid membrane lipid content by cultivating Synechocystis PCC 6803 in a medium containing titanium dioxide nanoparticles. It also provides a medium additive for microalgae cultivation using these same nanoparticles as an active ingredient.
Microalgae have gained attention as raw materials for functional foods, cosmetics, and pharmaceuticals due to their high photosynthetic efficiency. Among these, phycobiliproteins are in high demand as natural pigments and bioactive materials. However, existing cultivation methods struggle to increase intracellular content, and attempts to do so often inhibit cell growth, making it difficult to reduce mass production costs.
This technology adds trace amounts of titanium dioxide nanoparticles to the medium—relative to 100 parts by weight—to increase the production of phycocyanin, phycoerythrin, allophycocyanin, and phosphatidylglycerol-based membrane lipids without compromising cell growth. Applicable to the production of microalgae biomass for natural pigments, functional food ingredients, and cosmetics, it achieves increased yields simply by modifying the medium composition, without requiring expensive equipment.
This invention was developed with support from the Ministry of Science and ICT for research on marine microalgae for the production of light-regenerative substances based on metabolomics.
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