This technology features a food composition for improving hypertension and a pharmaceutical composition for preventing and treating hypertension, both containing germinated black bean extract obtained through hot-water extraction as an active ingredient. The extract lowers blood pressure by inhibiting the action of angiotensin-converting enzyme, a key enzyme in blood pressure elevation.
Angiotensin-converting enzyme is a primary cause of hypertension as it produces substances that constrict blood vessels and breaks down those that dilate them. Synthetic inhibitors like captopril and enalapril have been used to block this process. However, these drugs are associated with side effects such as taste disturbances, leukopenia, angioedema, and liver dysfunction, increasing the need for natural food-based alternatives suitable for long-term use.
This technology leverages nutritional changes during bean germination to produce a hot-water extract with higher enzyme inhibitory activity than non-germinated beans or ethanol/methanol extracts. Suitable raw materials include Seoritae, Seomoktae, and Heuktae, with Heuktae showing the most significant effect. Applicable to health functional foods, everyday items like soy beverages and soy milk, and natural anti-hypertensive supplements, this water-extracted grain material helps manage blood pressure consistently without the burden of side effects from synthetic drugs.
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