This technology is a composition that inhibits biofilm formation by methicillin-resistant Staphylococcus aureus (MRSA) MW2 by combining plant-derived fragrance ingredients: citral, hinokitiol, and linalool. The combination of these three components is designed to prevent the surface adhesion and colonization of antibiotic-resistant bacteria.
Staphylococcus aureus is a major pathogen that causes everything from skin infections to sepsis. With the global rise of methicillin-resistant strains, beta-lactam antibiotics have become ineffective. As strains resistant to vancomycin—the alternative treatment—have also emerged, existing antibiotic systems are struggling to cope. Furthermore, bacteria that form biofilms are particularly difficult to treat because they are resistant to drug penetration.
This technology uses a combination of naturally derived terpene and tropolone compounds, rather than antibiotics, to inhibit MRSA biofilm formation regardless of resistance mechanisms. Since these ingredients are already used as fragrances in food and cosmetics, they are easy to source and formulate. They can be applied to medical device and catheter coatings, hospital disinfectants and cleaners, and topical products for preventing skin infections, effectively blocking the initial stage where superbugs settle on surfaces to become sources of infection.
This invention was developed with support from the Ministry of Science, ICT and Future Planning for exploring the potential of newly discovered AMPK activators and binding proteins as regulators of blood glucose and cancer cell apoptosis.
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