This technology utilizes nasal lavage fluid collected from athletes after aerobic exercise as an active ingredient to create antimicrobial compositions, livestock feed additives, and disinfectant formulations effective against Staphylococcus aureus. It is characterized by leveraging the changes in defensive substances found in the nasal mucosa immediately following exercise as an antimicrobial agent.
Due to the misuse and overuse of antibiotics, resistant bacteria are increasing rapidly. Staphylococcus aureus has shown high resistance rates to various antibiotics, including tetracycline, and a significant number of strains isolated from livestock farms, such as pig and poultry farms, exhibit multidrug resistance. With the detection of vancomycin-resistant strains, there is an urgent need for new antimicrobial substances that minimize side effects and resistance issues even with long-term use.
This technology uses lavage fluid collected after performing aerobic exercise at a certain intensity or higher, characterized by an increase in heat shock protein HSP27 and a decrease in HSP70 compared to pre-exercise levels. It can be applied to antimicrobial feed additives for livestock, disinfectants for farms and meat processing facilities, and antimicrobial agents for managing Staphylococcus aureus infections, providing an alternative solution to reduce antibiotic dependency using bio-derived substances obtained from human exercise responses.
This invention was developed with support from the Ministry of Science and ICT for research into the role of human adenoid tissue in innate immunity.
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