Antifungal and aflatoxin-inhibiting composition containing strobilurin-based and flavonoid-based compounds

Antifungal composition that reduces chemical usage and resistance by combining strobilurin fungicides with baicalein or nobiletin in a 3–4:6–7 ratio

This technology is an antifungal and aflatoxin-inhibiting composition that combines strobilurin fungicides, such as azoxystrobin or pyraclostrobin, with flavone-based flavonoids, such as baicalein or nobiletin, in a weight ratio of 3–4 to 6–7. The two components act synergistically to inhibit plant pathogenic fungi such as Aspergillus, Alternaria, and Colletotrichum.

Strobilurin-based agents are widely used, accounting for over 20% of global fungicide sales. However, because they act on a single site by blocking mitochondrial electron transport, resistant strains emerged rapidly in crops like wheat and grapes. Since their efficacy drops after symptoms appear and spray drift can cause leaf browning in nearby apple varieties, alternatives to reduce application frequency and dosage are required.

This technology leverages the ability of natural flavone compounds to boost the antifungal and aflatoxin-inhibiting activity of strobilurins, allowing for the same level of control with less synthetic fungicide. It also inhibits toxin production by Aspergillus flavus and A. parasiticus. Applicable to mold toxin control in grains like peanuts and corn, crop protection for apple and pepper anthracnose and leaf spot, and feed additives to reduce mycotoxins, it lowers the risk of resistant strains and spray drift while ensuring aflatoxin safety in crops and feed.

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Key Features:

• Antifungal composition comprising a strobilurin-based compound, such as azoxystrobin or pyraclostrobin, and a flavone-based compound, such as baicalein or nobiletin
• Formulated composition containing a strobilurin-based compound and a flavonoid-based compound in a weight ratio of 3–4:6–7
• Composition with antifungal activity against one or more of Aspergillus flavus, Aspergillus parasiticus, Alternaria alternata, and Colletotrichum acutatum
• Plant disease control composition for antifungal use and aflatoxin production inhibition, containing the strobilurin and flavone combination as an active ingredient

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This invention was developed with support from the Ministry of Science and ICT for the discovery and validation of toxicity biomarkers in traditional natural products.

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