Novel cis-aconitate synthase and uses thereof

Novel cis-aconitate synthase for itaconic acid production

This technology relates to a novel cis-aconitate synthase variant and a recombinant microorganism for itaconic acid production incorporating the same.

Microbial production of itaconic acid has faced challenges in increasing productivity and yield due to limitations in existing metabolic pathways.

This technology utilizes a novel enzyme to establish an itaconic acid-specific carbon flux, separate from the existing TCA cycle, thereby significantly increasing productivity and yield. It can be applied in the synthetic resin, latex, and food additive industries.

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Key Features:

• Novel cis-aconitate synthase variant
• Recombinant microorganism for itaconic acid production incorporating the enzyme
• Itaconic acid-specific carbon flux separated from the existing TCA cycle
• Significant improvement in itaconic acid productivity and yield