Protease sensor for disease diagnosis and drug screening

This technology is about a sensor for proteolytic enzyme detection using a metal nanoparticle-nucleic acid-peptide complex.

To solve the problems of high cost, long time, and low stability of protein detection methods, an innovative sensor using a metal nanoparticle-nucleic acid-peptide complex was developed. This technology specifically emits strong fluorescence when a peptide is degraded by a specific proteolytic enzyme, quickly and accurately measuring the proteolytic enzyme.

This technology can be used in a variety of fields, including cell-based non-destructive and real-time measurement, body fluid-based on-site disease diagnostic kits, drug screening, and cell and tissue imaging. In particular, it is a platform that can contribute to the early diagnosis and development of treatments for major diseases such as cancer, arthritis, and neurological diseases.

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Key Features:

• It operates like a switch on and off the fluorescent signal by controlling the distance between the gold nanoparticle and the fluorescent substance using the Metal-Enhanced Fluorescence (MEF) phenomenon.
• Off state (Fluorescence quenching): Normally, the fluorescent substance is connected to the surface of the gold nanoparticle by peptide and DNA and maintains a very close distance.
• On state (Fluorescence amplification): When a specific proteolytic enzyme appears and cleaves the peptide, the distance between the fluorescent substance and the gold nanoparticle increases. As it moves further away, the optimal distance of about 8 nm is secured, the quenching effect disappears and the fluorescence signal is amplified dozens of times.
• Label-free method that does not require a separate label, allowing users to measure proteins more easily and quickly

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This technology was developed through support from the Research Fellow research project of the National Research Foundation of Korea.

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Methane conversion reaction bed regeneration using low-temperature plasma

This technology relates to a method of regenerating a deactivated methane dimerization reaction bed in a dielectric barrier discharge plasma reactor.

In the existing technology, carbon deposition (coke) on the reaction bed occurring in the methane dimerization process reduced catalyst activity and made regeneration difficult. This technology utilizes dielectric barrier discharge (DBD) plasma to effectively remove coke in the deactivated methane dimerization reaction bed by low-temperature plasma treatment in an oxidizing atmosphere.

This technology's 'in-situ regeneration' method preserves the catalyst structure compared to existing high-temperature heat treatment, increases energy efficiency, and can continuously produce C2+ hydrocarbons (ethylene, ethane) and hydrogen from methane with high efficiency.

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Key Features:

• C-H bonding of methane under room temperature and pressure conditions using dielectric barrier discharge (DBD) plasma, a type of low-temperature plasma.
• Conversion of methane into high value-added hydrocarbons such as C2 or higher, such as ethane, ethylene, and acetylene, and hydrogen, without additional heat energy or oxidizing agent.
• Removal of coke by injecting an oxygen-containing mixture (e.g., air) within the same DBD plasma reactor.
• Methane Continuous operation is possible by repeating the conversion (step 1) and bed regeneration (step 2) processes more than once as needed

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This technology was developed through the support of the National Research Foundation of Korea's research project on 3D graphene with a highly regular pore structure for CO hydrogenation reaction.

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Methane conversion reaction bed regeneration using low-temperature plasma

This technology relates to a method of regenerating a deactivated methane dimerization reaction bed in a dielectric barrier discharge plasma reactor.

In the existing technology, carbon deposition (coke) on the reaction bed occurring in the methane dimerization process reduced catalyst activity and made regeneration difficult. This technology utilizes dielectric barrier discharge (DBD) plasma to effectively remove coke in the deactivated methane dimerization reaction bed by low-temperature plasma treatment in an oxidizing atmosphere.

This technology's 'in-situ regeneration' method preserves the catalyst structure compared to existing high-temperature heat treatment, increases energy efficiency, and can continuously produce C2+ hydrocarbons (ethylene, ethane) and hydrogen from methane with high efficiency.

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Key Features:

• C-H bonding of methane under room temperature and pressure conditions using dielectric barrier discharge (DBD) plasma, a type of low-temperature plasma.
• Conversion of methane into high value-added hydrocarbons such as C2 or higher, such as ethane, ethylene, and acetylene, and hydrogen, without additional heat energy or oxidizing agent.
• Removal of coke by injecting an oxygen-containing mixture (e.g., air) within the same DBD plasma reactor.
• Methane Continuous operation is possible by repeating the conversion (step 1) and bed regeneration (step 2) processes more than once as needed

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This technology was developed through the support of the National Research Foundation of Korea's research project on 3D graphene with a highly regular pore structure for CO hydrogenation reaction.

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Method for manufacturing a cream sauce for fish using blanched broccoli and white roux

This technology is a method for producing a fish sauce by blending and grinding blanched broccoli and sautéed onions with white roux, milk, whipping cream, chicken stock, and spices.

Previously, it was difficult to create a sauce that complements fish dishes while reducing fishy odors and preserving the nutritional value and flavor of broccoli.

By blending and grinding blanched broccoli and sautéed ingredients with cream and spices, this technology can be applied to fish sauce products, such as those for mackerel, to enhance both flavor and nutrition.

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Key Features:

• A step of preparing broccoli for the sauce by blanching it at 90–110°C for 30–40 seconds
• A step of preparing sautéed ingredients by stir-frying the blanched broccoli and onions in butter at 90–110°C
• A step of adding white roux, milk, whipping cream, water, liquid chicken stock, ginger juice, and spices to the sautéed ingredients, followed by grinding in a blender
• A step of completing the sauce by adding aromatic ingredients, such as bay leaves, to the ground mixture in specified proportions

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This patent is owned by IPBank. Upon purchase, you may receive support through commercialization programs, recommendations for technology transfer and commercialization funding guarantees, and bonus points during evaluations for priority procurement of excellent inventions.

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Gap-free rotating insect-proof window system

This technology is about a revolving window and is about a window that can add an insect-proof function without any play during the opening and closing process of the window.

Existing revolving windows had difficulty integrating insect screens and were inconvenient in cleaning the outside. This technology proposes a ‘rotating insect-proof window system’ that solves these problems.

This system is designed so that the insect screen operates without play when opening or closing the window through the organic interconnection of the external frame, internal frame, slideable insect prevention roll, and moving guide. It is attractive in appearance, takes up minimal space, and makes outdoor window cleaning safe and convenient.

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Key Features:

• Internal frame: Rotates around the axis of rotation, forming 'circulating rails' at the top and bottom
• Insect prevention roll: One end is fixed to the external frame, the other end slides according to the movement of the internal frame
• Movement guide: Connects the end of the insect prevention roll to the circular rail of the internal frame, guiding the insect screen to move together along the rail when the internal frame rotates
• When the window is closed, the insect screen returns to the roll housing in the reverse order. Automatically wound inside

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Cognitive training method using automated respiratory resistance to guide breathing

This technology provides respiratory training content to a user terminal and calculates breathing patterns based on data measured by a respiratory interface. It then adjusts inhalation and exhalation resistance if the patterns deviate from established standards.

Existing cognitive training methods often fail to quantitatively reflect respiratory states and struggle to guide or adjust a user's breathing in real time, limiting the effectiveness of the training.

By adjusting the inhalation and exhalation resistance of the interface when breathing patterns fall outside the target range, this technology guides users toward normal breathing, making it ideal for cognitive training services that aim to improve both respiratory control and cognitive function.

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Key Features:

• Providing respiratory training content to a user terminal and receiving respiratory data measured by the interface
• Calculating breathing patterns based on the received data and determining whether they fall within the target range
• Adjusting the inhalation or exhalation resistance of the interface when breathing patterns deviate from the target range
• Calculating the normal breathing ratio and cognitive improvement rate based on performance data derived from breathing patterns

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This patent is owned by IP Bank. Upon purchase, you may receive support through commercialization programs, recommendations for technology transfer and commercialization funding guarantees, and additional points during evaluations for priority procurement of excellent inventions.

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Real-time restoration of high-quality 3D ultrasound images without blurring

This technology relates to a 3D ultrasound image restoration method and its ultrasound imaging device. It concerns a method of restoring high-definition ultrasound images based on 3D ultrasound echo signals focused for each pixel based on the resolution of the target cross-section.

Blurring artifacts and excessive computation that occurred during existing 3D ultrasound image restoration were problems that hindered the accuracy of diagnosis. This technology presents a new 3D ultrasound image restoration method and device to solve these problems.

Based on the 3D ultrasound echo signal obtained from the object, the transmission and reception delay time and phase value are calculated using the physical location information of the target cross section, and through this, the echo signal is phase rotated to obtain a high quality signal value. This technology effectively eliminates image distortion and blurring artifacts by omitting the digital scan conversion process, and minimizes the amount of calculation to create clear, high-contrast, high-definition 3D ultrasound images.

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Key Features:

• Omit the digital scan conversion process, which is the main cause of blurring artifacts
• Directly calculate and restore the signal value corresponding to each pixel (second coordinate system) of the final image from the ultrasonic echo signal (first coordinate system)
• Calculate the precise transmission/reception delay time for each pixel, and convert this to a phase value to phase rotate the signal
• Restore the high-definition ultrasound image of the target cross-section based on the finally obtained signal values

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This technology was developed through the National Research Foundation of Korea's ultrasound-based patch-type bladder monitoring healthcare system research project.

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Osteoporosis treatment composition containing D3G compound derived from Lycii Cortex

This technology is a pharmaceutical composition for the prevention and treatment of osteoporosis that contains the dihydrophaseic acid D3G compound isolated from Lycii Cortex extract as an active ingredient.

Existing osteoporosis compositions often lacked clearly defined active ingredients, leading to low reproducibility of efficacy, and there were difficulties in identifying and isolating active compounds from Lycii Cortex.

By using the D3G compound isolated and purified from Lycii Cortex extract as an active ingredient, this technology can be applied to osteoporosis treatments and functional foods to prevent and treat the condition.

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Key Features:

• A pharmaceutical composition containing dihydrophaseic acid D3G of Formula 1, isolated from Lycii Cortex extract, as an active ingredient
• A step of suspending Lycii Cortex extract in water and fractionating it with organic and aqueous solvents to obtain an aqueous fraction
• A step of obtaining primary sub-fractions from the aqueous fraction using open column chromatography with water and methanol
• A step of isolating and purifying the D3G compound from the primary sub-fractions using column chromatography

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This patent is owned by IPBank. Upon purchase, you may receive support through commercialization programs, recommendations for technology transfer and commercialization funding guarantees, and additional points during the evaluation for priority procurement of excellent inventions.

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Korean power rate optimization ESS peak reduction system

This technology relates to an energy storage device operation method and system based on the Korean power rate system. It relates to an energy storage device operation method and system based on the Korean power rate system that can reduce the peak value of the actual power load pattern and the total power bill by controlling the charge and discharge operation of the energy storage device by calculating the optimized charge/discharge ratio of the energy storage device according to the results of comparative analysis of the peak value for predicted demand power and the actual accumulated peak value.

Korea's existing unique power rate system determines the base rate based on the maximum peak load over the past 12 months, making it difficult to substantially reduce electricity costs using energy storage systems (ESS) alone.

To solve these problems, this technology predicts the peak value of power demand for the current month based on past power usage data and compares it with the cumulative peak value of the past few months to calculate the optimal charging/discharging ratio of the ESS. It helps reduce overall electricity costs by simultaneously achieving peak load management and time-based rate reduction.

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Key Features:

• Predict the demand power peak value for the current month based on past power usage data
• Compare and analyze the predicted peak value and the actual cumulative peak value of the past few months
• Calculate the optimal charge/discharge ratio of the energy storage device according to the comparative analysis results, and control the system to reduce the next day's peak load through this
• Apply the Robust Optimization technique that takes into account the error in the predicted load, effectively dealing with the uncertainty of the actual power usage environment response

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This technology was developed through support from the Korea Institute of Energy Technology Evaluation and Planning's smart grid core technology development research project.

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Composition for preventing osteoporosis containing Lycii Radicis Cortex ethanol extract as an active ingredient

This technology relates to a composition for preventing osteoporosis that contains a specific concentration of Lycii Radicis Cortex ethanol extract, obtained by hot-air drying and pulverizing Lycii Radicis Cortex, extracting it with water and ethanol, and then performing centrifugation and vacuum concentration.

Preventing and improving bone metabolic diseases requires active ingredients that enhance bone function, yet there has been a lack of compositions derived from natural sources that reliably provide effective concentrations.

By incorporating Lycii Radicis Cortex extract at a specific concentration within the total composition, this technology secures bone function improvement activity, allowing it to be applied to compositions for preventing osteoporosis to help prevent and improve bone metabolic diseases.

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Key Features:

• Composition for preventing osteoporosis containing Lycii Radicis Cortex extract at a concentration of 10 ug/ml to 50 ug/ml of the total composition
• Lycii Radicis Cortex prepared by hot-air drying at 50–60°C and pulverizing to a size of 60 mesh or less
• Lycii Radicis Cortex extract obtained by adding water and ethanol to pulverized Lycii Radicis Cortex and extracting at 80°C for 4 hours
• Lycii Radicis Cortex ethanol extract obtained by centrifuging the extract, followed by vacuum concentration, filtration, and secondary vacuum concentration

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This patent is owned by IPBank. Upon purchase, you may receive support through commercialization programs, recommendations for technology transfer and commercialization funding guarantees, and additional points during the evaluation for priority procurement of excellent inventions.

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Blockchain-based smart contract to reduce traffic

This technology is about a distributed consensus system and method for the external interface in a blockchain-based smart contract. It is about an external device call interface that enables external device calls and a blockchain-based external service support system using public key verification.

The reason external device calls cannot be made in existing blockchain-based smart contracts is because smart contracts are executed on all nodes.

This technology uses transaction application methods of block generation nodes and block verification nodes to solve the problem of not being able to call external devices. By separating, traffic generated from external devices can be reduced.

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Key Features:

• When creating a block, if there is a request to call an external device, the block generation node directly calls it and stores the response in the block
• The external device signs and sends its response with a public key-based structure
• The block verification node verifies the transaction by checking whether the response stored in the block is correctly configured through public key verification
• All networks agree on the response content

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Pretreatment method for recycled seashells combining ultrasonic waves and acid washing

This technology is a pretreatment method for recycled seashells that involves washing, soaking, ultrasonic irradiation, and drying, followed by acid washing in an aqueous acid solution and inspection of whiteness and strength.

To recycle seashells, surface contaminants and organic matter must be thoroughly removed; however, conventional washing methods have struggled to achieve the necessary levels of whiteness and strength.

By precisely treating seashells through ultrasonic irradiation and specific acid washing processes, this technology ensures high whiteness and strength when applied to recycled seashell raw materials.

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Key Features:

• Washing and soaking stage: Washing seashells multiple times in running water and soaking them in distilled water for 24 hours.
• Ultrasonic stage: Irradiating the seashells with ultrasonic waves three times for 30 minutes each after the soaking stage.
• Acid washing stage: Immersing the dried seashells in an aqueous acid solution after the ultrasonic stage.
• Measurement stage: Inspecting the whiteness and strength of the seashells after drying them following the acid wash.

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This patent is owned by IP Bank. Upon purchase, you may receive support through commercialization programs, recommendations for technology transfer and commercialization funding guarantees, and bonus points during the evaluation for priority procurement of excellent inventions.

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Automatic separation blister packing device without damaging tablets

This technology is about a device for dispersing blister packing tablets without damaging the tablets when supplying tablets.

Existing manual blister tablet extraction consumes a lot of time and manpower, and there is a risk of tablet damage and contamination. To solve this problem, this technology provides a packaging device that automatically separates and extracts blister-packed tablets without damaging the tablets.

This device precisely forms a sheath at the bottom of the blister package and safely extracts the tablets through pressurization, ensuring efficiency and hygiene at the same time. It is an optimized solution for environments that require separation of large quantities of tablets, such as pharmacies and hospitals.

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Key Features:

• Guide part: Guides blister-packed tablets of various sizes to be placed in the correct position
• Cutting roller part: Precisely forms a sheath along the line where the tablet is located on the lower part of the inserted packaging material (aluminum foil)
• Pressure roller part: Gently presses the notched packaging material from above, allowing the tablet to come out of the pocket with minimal pressure.
• The path along which the packaging material moves is slanted downward, Designed so that the extracted tablets fall safely forward without hitting the roller shaft and are collected in a designated collection box

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Xylene yield enhancing hierarchical MFI zeolite

This technology simultaneously uses a non-benzene-based first structure directing agent that provides the skeletal structure of MFI zeolite seed crystals with regular microporous pore sizes, and a second structure directing agent containing one benzene ring and ammonium ion that acts as a mesopore-directing agent without interfering with the role of the first structure directing agent. This is about the manufacturing method of hierarchically structured MFI zeolite.

We overcome the mass transfer limitations of existing MFI zeolites and present a solution for the production of acetylene-based sustainable aromatics.

The catalyst using this technology maintains the excellent properties of existing zeolites while maximizing mass transfer efficiency, showing excellent catalytic activity in the conversion reaction from acetylene to high value-added aromatic compounds such as benzene, toluene, and xylene. In particular, it can contribute to the development of a sustainable chemical industry by improving xylene production yield by up to 7 times

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Key Features:

• Using two types of structure-directing agents (SDA) simultaneously to manufacture MFI zeolite with a hierarchical structure in which micropores and mesopores coexist
• First structure-directing agent: A non-benzene-based directing agent (e.g. tetrapropylammonium hydroxide) forms a regular microporous structure that becomes the skeleton of MFI zeolite
• Second structure-directing agent: Containing a benzene ring Cationic surfactant (e.g., benzyltrimethylammonium bromide) additionally forms mesopores without interfering with the formation of microstructure
• Excellent performance in the conversion reaction from acetylene to aromatic compounds, significantly increasing aromatic compound yield by about 2 times compared to existing catalysts, and especially xylene yield by about 7 times

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This technology was developed through the National Research Foundation of Korea's research project on catalyst technology for producing BTX from methane via acetylene.

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Xylene yield enhancing hierarchical MFI zeolite

This technology simultaneously uses a non-benzene-based first structure directing agent that provides the skeletal structure of MFI zeolite seed crystals with regular microporous pore sizes, and a second structure directing agent containing one benzene ring and ammonium ion that acts as a mesopore-directing agent without interfering with the role of the first structure directing agent. This is about the manufacturing method of hierarchically structured MFI zeolite.

We overcome the mass transfer limitations of existing MFI zeolites and present a solution for the production of acetylene-based sustainable aromatics.

The catalyst using this technology maintains the excellent properties of existing zeolites while maximizing mass transfer efficiency, showing excellent catalytic activity in the conversion reaction from acetylene to high value-added aromatic compounds such as benzene, toluene, and xylene. In particular, it can contribute to the development of a sustainable chemical industry by improving xylene production yield by up to 7 times

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Key Features:

• Using two types of structure-directing agents (SDA) simultaneously to manufacture MFI zeolite with a hierarchical structure in which micropores and mesopores coexist
• First structure-directing agent: A non-benzene-based directing agent (e.g. tetrapropylammonium hydroxide) forms a regular microporous structure that becomes the skeleton of MFI zeolite
• Second structure-directing agent: Containing a benzene ring Cationic surfactant (e.g., benzyltrimethylammonium bromide) additionally forms mesopores without interfering with the formation of microstructure
• Excellent performance in the conversion reaction from acetylene to aromatic compounds, significantly increasing aromatic compound yield by about 2 times compared to existing catalysts, and especially xylene yield by about 7 times

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This technology was developed through the National Research Foundation of Korea's research project on catalyst technology for producing BTX from methane via acetylene.

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