This technology is a cosmetic composition containing the naturally derived compound nerol, commonly used as a fragrance, or its acceptable salts as an active ingredient. It aims to improve skin wrinkles and loss of elasticity exacerbated by stress, and also serves as a reagent to reduce stress-response-related cellular signaling.
Chronic mental and environmental stress is known to trigger the continuous release of stress hormones, which reduces collagen synthesis in the dermis and accelerates skin aging. While stress-induced skin aging is becoming more prevalent due to increased UV exposure and fine dust, there has been a lack of cosmetic ingredients that target the stress response itself while remaining safe for long-term use.
This technology leverages the ability of nerol to inhibit stress-related gene expression in skin fibroblasts and nerve cells while increasing procollagen levels. As a naturally derived ingredient with proven safety as a fragrance and food additive, it is ideal for addressing chronic, recurring stress-related skin concerns. It can be applied to anti-aging creams, serums, stress-care derma cosmetics, and functional aromatherapy skincare, allowing for product development that offers both sensory fragrance benefits and wrinkle/elasticity improvement in a single ingredient.
This invention was developed with support from the Ministry of Science and ICT for research into the collagen production regulation system in the dermis mediated by skin olfactory receptors.
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