Composition for preventing or treating allergic diseases or atopic dermatitis comprising thiazole or a salt thereof as an active ingredient

Pharmaceutical and cosmetic composition for multi-allergic diseases based on thiazole active ingredients

This technology is a composition for preventing and treating allergic diseases and atopic dermatitis using thiazole, a sulfur- and nitrogen-containing five-membered ring compound, or its salts as an active ingredient. All independent claims specify concrete disease groups, including edema, anaphylaxis, rhinitis, asthma, conjunctivitis, and allergies to insects, food, and drugs.

While existing atopic and allergy medications like steroids are useful for acute exacerbations, long-term use has been associated with skin atrophy and potential systemic side effects. Topical immunomodulators also lack established safety profiles, creating a need for low-irritation alternatives suitable for a wide range of allergic symptoms.

This technology leverages the anti-allergic effects of thiazole, which reduces the expression of Th2-type cytokines and inflammatory factors, as well as histamine secretion. It can be applied to quasi-drugs for conjunctivitis and rhinitis, anti-itch products for insect bites, and health functional foods for food allergy management, allowing a single ingredient patent to support a diversified line of allergy products.

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Key Features:

• A pharmaceutical composition for the prevention or treatment of allergic diseases or atopic dermatitis comprising thiazole or a pharmaceutically acceptable salt thereof as an active ingredient
• The composition wherein the target allergic disease is one or more of edema, anaphylaxis, allergic rhinitis, asthma, allergic conjunctivitis, urticaria, insect allergy, or drug allergy
• A pharmaceutical composition wherein the active ingredient reduces the expression of IL-4, IL-13, TNF-α, IL-1β, IL-6, or IL-8, or reduces histamine secretion
• A cosmetic, fragrance, quasi-drug, and health functional food composition for allergy improvement comprising thiazole or a cosmetically or food-grade acceptable salt thereof as an active ingredient

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This invention was developed with support from the Ministry of Education, Science and Technology for research on the skin anti-aging effects of suberic acid via olfactory receptors.

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