Composition for the prevention or treatment of allergic diseases or atopic dermatitis comprising ethyl vanillin or a salt thereof as an active ingredient

Ethyl vanillin-based composition for atopic skin care by inhibiting histamine release

This technology utilizes ethyl vanillin, a vanilla-based fragrance ingredient, or its salts as an active ingredient for the prevention and treatment of atopic dermatitis. In addition to pharmaceutical compositions, the claims independently cover quasi-drugs, cosmetic, fragrance, and health functional food compositions.

Topical steroids used for severe atopic dermatitis are unsuitable for long-term management due to increased tolerance and skin side effects depending on frequency, concentration, and duration of use. Immunomodulators for mild or maintenance therapy also have reported side effects ranging from burning sensations and acne to lymphoma, leaving a shortage of gentle, everyday alternatives.

This technology is based on the ability of ethyl vanillin to reduce itching and inflammation by inhibiting the expression of inflammatory cytokines and the release of histamine. As a familiar fragrance ingredient, it can be applied to moisturizing lotions for infants and sensitive skin, body washes, and scented household products, allowing for the development of products that combine soothing atopic relief with a subtle vanilla scent.

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Key Features:

• Pharmaceutical composition for the prevention or treatment of atopic dermatitis comprising ethyl vanillin or a pharmaceutically acceptable salt thereof as an active ingredient
• Composition for treating atopic dermatitis wherein the active ingredient reduces the expression of IL-4, IL-13, TNF-α, IL-1β, IL-6, or IL-8, or the amount of histamine release
• Cosmetic and fragrance compositions for the prevention or improvement of atopic dermatitis comprising ethyl vanillin or a cosmetically acceptable salt thereof as an active ingredient
• Quasi-drug and health functional food compositions for the improvement of atopic dermatitis comprising ethyl vanillin or a pharmaceutically or nutritionally acceptable salt thereof as an active ingredient

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This invention was developed with support from the Ministry of Education, Science and Technology for research on the skin anti-aging effects of suberic acid via olfactory receptors.

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