Composition for the prevention or treatment of allergic diseases or atopic dermatitis comprising suberic acid or a salt thereof as an active ingredient.

Composition for Improving Allergic Diseases Including Rhinitis, Asthma, and Urticaria Using Suberic Acid

This technology is a composition for the prevention and treatment of allergic diseases and atopic dermatitis, featuring suberic acid—a dicarboxylic acid found in plant essential oils such as hollyhock and castor—or its salts as an active ingredient. The target conditions extend beyond dermatitis to include allergic rhinitis, asthma, conjunctivitis, and food or drug allergies.

Steroids, widely used to manage allergy and atopy symptoms, carry risks of systemic side effects such as skin atrophy, HPA axis suppression, and Cushing's syndrome with long-term use. Non-steroidal alternatives like tacrolimus and pimecrolimus also lack sufficient safety profiles, creating an urgent need for safer complementary ingredients.

This technology leverages the efficacy of suberic acid in suppressing allergic inflammation by simultaneously reducing the expression of IL-4, IL-13, TNF-α, IL-1β, IL-6, and IL-8, as well as histamine secretion. It can be applied to pharmaceuticals and health supplements targeting systemic allergy symptoms like rhinitis and urticaria, as well as topical skin treatments, allowing for a product line that addresses both skin and respiratory allergies.

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Key Features:

• A pharmaceutical composition for the prevention or treatment of allergic diseases or atopic dermatitis comprising suberic acid or a pharmaceutically acceptable salt thereof as an active ingredient.
• The composition wherein the allergic disease is one or more of edema, hypersensitivity, allergic rhinitis, asthma, allergic conjunctivitis, contact dermatitis, urticaria, pruritus, or food allergy.
• A pharmaceutical composition wherein the active ingredient reduces the expression of IL-4, IL-13, TNF-α, IL-1β, IL-6, or IL-8 and decreases histamine secretion.
• A quasi-drug, cosmetic, fragrance, and health functional food composition comprising suberic acid or a cosmetically or food-grade acceptable salt thereof as an active ingredient.

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This invention was developed with support from the Ministry of Education, Science and Technology for research on the skin anti-aging effects of suberic acid via olfactory receptors.

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