Composition for the prevention or treatment of allergic diseases or atopic dermatitis comprising camphor or a salt thereof as an active ingredient

Atopic dermatitis improvement material using camphor to reduce inflammatory cytokines

This technology utilizes camphor, a component well-known for its presence in ginseng, or its salts as an active ingredient in compositions designed to prevent and alleviate atopic dermatitis. It is highly versatile, applicable to pharmaceutical compositions, quasi-drugs, cosmetics, fragrances, and health functional foods.

Topical steroids used for atopic dermatitis have long been limited by side effects such as skin atrophy, telangiectasia, and steroid-induced acne, as well as issues with drug resistance. Alternative topical immunomodulators also face limitations due to unresolved safety concerns, including potential kidney function decline and skin cancer risks.

This technology is based on camphor's efficacy in suppressing atopic symptoms by reducing the expression of inflammatory cytokines—such as IL-4, IL-13, and TNF-α—and inhibiting histamine release. It can be applied to topical skin products like ointments and creams, as well as fragrance products, allowing for the integration of refreshing aromatic properties and soothing functions into a single product.

‍

‍

Key Features:

• Pharmaceutical composition for the prevention or treatment of atopic dermatitis comprising camphor or a pharmaceutically acceptable salt thereof as an active ingredient
• Pharmaceutical composition wherein the active ingredient reduces the expression of IL-4, IL-13, TNF-α, IL-1β, IL-6, or IL-8, as well as histamine secretion
• Cosmetic and fragrance compositions for improving atopic dermatitis comprising camphor or a cosmetically acceptable salt thereof as an active ingredient
• Quasi-drug and health functional food compositions for the prevention or improvement of atopic dermatitis comprising camphor or a salt thereof as an active ingredient

‍

This invention was developed with support from the Ministry of Education, Science and Technology for research on the skin anti-aging effects of suberic acid via olfactory receptors.

‍