This technology is a transdermal absorption-promoting composition that enhances skin penetration by using siRNA as an active ingredient to specifically inhibit the expression of the nephrin gene, known as a renal podocyte protein. It loosens the tight junctions between keratinocytes, allowing external active ingredients to penetrate the skin more effectively.
While transdermal administration offers the advantage of bypassing first-pass metabolism in the liver, the skin barrier itself acts as a rate-limiting factor, significantly restricting the absorption of hydrophilic or salt-form drugs. Existing absorption-promoting methods, such as liposomes, nanoparticles, and ultrasonic devices, are not endogenous substances, raising concerns about side effects like intradermal immune responses.
This technology assists in the intradermal delivery of pharmaceutical or cosmetic ingredients by reducing nephrin expression in the skin to loosen tight junctions. It can be applied to functional cosmetics for whitening, moisturizing, and anti-wrinkle effects, as well as hair removal or tattoo preparations and microneedle-based delivery platforms, serving as an auxiliary material that boosts perceived absorption rates without requiring changes to existing formulations.
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