This technology is a drug delivery system that loads doxorubicin into plant-derived extracellular vesicles isolated from red cabbage tissue via size-exclusion chromatography for delivery into human cells. Red cabbage-derived vesicles are spherical and exhibit higher drug-loading capacity than those derived from human cells or black soybeans.
Extracellular vesicles, which have been studied as drug carriers, are mostly obtained from human cell cultures. Securing the quantities required for human application necessitates large-scale cultivation, which imposes significant burdens in terms of costs, equipment, and technology. Furthermore, challenges in ensuring production volume and uniformity have limited their supply as commercial-scale nanocarrier materials.
By using red cabbage—a globally common Brassica vegetable—as a raw material, this technology enables the isolation of vesicles without cell culture, facilitating low-cost, large-scale production. It efficiently delivers nucleic acids or chemically synthesized drugs to human cells. Applicable to anticancer nanocarriers, cosmetic skin-delivery agents, and functional food ingredients, it paves the way for replacing human cell-derived vesicles with plant-based materials.
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