This technology is a composition for preventing and treating muscle diseases, featuring straight-chain alkanes with 14 to 17 carbon atoms, including tetradecane and heptadecane, or their salts as active ingredients. It covers pharmaceutical compositions, as well as health functional foods and cosmetic formulations for improving muscle function.
While muscle function decline, muscle atrophy, and sarcopenia are increasing rapidly with an aging population, there has been a lack of safe materials that simultaneously increase muscle protein synthesis and inhibit its degradation. Existing approaches have limitations, such as restricted efficacy or unsuitability for long-term consumption, making them difficult to use in daily life.
This technology works by having straight-chain alkanes increase the expression of muscle protein synthesis-related proteins, such as p-4E-BP1 and p-p70S6K1, in muscle cells, while decreasing the expression of MuRF1, MaFbx, and myostatin, thereby promoting muscle differentiation, regeneration, and increased muscle mass. It can be applied to the management of muscle-wasting diseases like muscular atrophy, cachexia, and sarcopenia, as well as in health functional foods and body cosmetics for muscle function improvement, allowing for both therapeutic and daily-use products to be developed from a single material.
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