Composition for anti-allergy, atopic dermatitis improvement, or skin regeneration containing guaiyl acetate as an active ingredient

Material for Alleviating Allergy and Atopic Dermatitis Using Guaiyl Acetate

This technology utilizes guaiyl acetate, a sesquiterpene ester fragrance component, or its salts as an active ingredient in a composition for managing atopic dermatitis and specific allergic conditions, including edema, hypersensitivity, rhinitis, asthma, and hives.

Allergic diseases, including atopy, are caused by a complex interplay of factors such as genetics, diet, allergens, and skin barrier dysfunction, making them difficult to manage with single-mechanism drugs. While steroid and immunosuppressant-based treatments are effective for severe symptoms, they carry risks of side effects with repeated use.

Based on the efficacy of guaiyl acetate in reducing inflammatory responses by suppressing the expression of IL-1β, IL-6, IL-8, IL-4, and IL-13, this technology clearly defines its scope by specifying the target allergic disease groups. As it is a familiar fragrance ingredient, it can be applied to soothing perfumes, body care products, atopy-improving foods, and anti-allergy pharmaceuticals, enabling the development of products that combine fragrance with therapeutic benefits.

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Key Features:

• A pharmaceutical composition for treating allergic diseases selected from edema, hypersensitivity, rhinitis, asthma, and conjunctivitis, containing guaiyl acetate or a pharmaceutically acceptable salt as an active ingredient
• A composition for preventing or treating atopic dermatitis that reduces the expression of IL-4, IL-13, TNF-α, IL-1β, IL-6, or IL-8 through the action of guaiyl acetate as an active ingredient
• A composition containing guaiyl acetate or its salts for preventing or improving contact dermatitis, hives, pruritus, and insect, food, or drug allergies
• A composition containing guaiyl acetate for preventing or improving allergic diseases and atopic dermatitis, provided in the form of functional foods, cosmetics, or fragrance compositions

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This invention was developed with support from the Ministry of Education, Science and Technology’s research project on identifying olfactory receptors that act as drug targets for anti-obesity phytochemicals.

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