Composition for the improvement, prevention, or treatment of atopic dermatitis containing Cornus walteri stem extract as an active ingredient

Composition for Alleviating Atopic Inflammation and Strengthening the Skin Barrier Using Cornus walteri Stem Extract

This technology utilizes Cornus walteri stem extract as an active ingredient to prevent, improve, and treat atopic dermatitis by reducing the expression of eotaxin-3, TARC, and MDC, while increasing filaggrin (FLG) gene expression.

Atopic dermatitis is a chronic, recurrent inflammatory disease accompanied by itching, with an increasing number of adult patients in addition to children. Symptom-focused treatments using long-term topical corticosteroids and calcineurin inhibitors have been associated with side effects and drug resistance issues.

This technology demonstrates a dual effect: the Cornus walteri stem extract simultaneously inhibits atopic inflammatory chemokines at both the protein and gene levels while restoring the expression of damaged skin barrier proteins. It can be applied to natural medicinal products for atopic treatment and barrier-strengthening moisturizing cosmetics, effectively meeting the demand for reducing long-term steroid use.

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Key Features:

• Pharmaceutical composition for preventing, improving, or treating atopic dermatitis containing Cornus walteri stem extract as an active ingredient and reducing eotaxin-3, TARC, and MDC expression
• Cornus walteri stem extract composition targeting atopic dermatitis induced by one or more cytokines among IL-4, IL-13, IFN-γ, TARC, and MDC
• Composition for improving atopic dermatitis containing Cornus walteri stem extract that strengthens the skin barrier and alleviates inflammation by increasing FLG gene expression
• Cosmetic composition for improving atopic dermatitis that reduces eotaxin-3 or TARC at the protein level and inhibits TARC or MDC gene expression

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