This technology utilizes fucosterol, a sterol compound found in seaweeds such as kelp, wakame, hijiki, and ecklonia cava, as an active ingredient in cosmetic, food, and pharmaceutical compositions for skin brightening.
Skin tone is largely determined by melanin biosynthesis, driven by the tyrosinase enzyme in melanocytes. Excessive production due to UV rays, hormones, or stress leads to dark spots and pigmentation. While there has been high demand for natural whitening agents to inhibit this, ingredients that are both effective and safe have been limited.
This technology demonstrates that fucosterol inhibits both tyrosinase activity and melanin production, while also confirming moisturizing effects through the promotion of keratinocyte differentiation and natural moisturizing factor production. It can be applied to whitening cosmetics, ingestible whitening supplements, and treatments for pigmentary disorders, contributing to the high-value development of marine bio-ingredients.
This invention was developed with support from the Ministry of Oceans and Fisheries for the acquisition and basic physiological activity analysis of Indonesian marine bio-resources.
CN106413678B, JP6474418B2, US9956157B2, WO2015-111953A1