Composition for improving or alleviating stress-induced diseases comprising an ethyl acetoacetate compound as an active ingredient

Composition for alleviating stress-induced neurological and skin disorders using ethyl acetoacetate

This technology is a cosmetic, food, pharmaceutical, or fragrance composition that uses ethyl acetoacetate compounds or their salts as an active ingredient to improve stress-induced neurological disorders—such as depression, sleep disorders, anxiety disorders, and panic disorders—as well as stress-induced skin conditions.

Excessive mental stress causes sustained cortisol secretion via the HPA axis, which damages neurons and creates a vicious cycle of anxiety, depression, and sleep disorders. The skin is also a target for stress hormones, leading to the worsening of dermatitis, hair loss, and acne, yet there are few materials that address both the nervous system and the skin simultaneously.

This technology leverages the ability of ethyl acetoacetate to inhibit glucocorticoid-responsive gene expression in fibroblasts and neurons, targeting both emotional symptoms and skin conditions such as alopecia areata, lichen simplex chronicus, prurigo, and dyshidrotic eczema. It can be applied to aroma-based sleep and relaxation products, stress-care cosmetics, and mental health supplements, opening a path for the long-term management of chronic stress-related conditions through everyday products.

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Key Features:

• Cosmetic composition for improving or alleviating stress-induced neurological, skin, and infectious diseases, comprising an ethyl acetoacetate compound or a cosmetically acceptable salt as an active ingredient
• Food composition containing ethyl acetoacetate, wherein the stress-induced neurological disorder is selected from the group consisting of depression, sleep disorders, anxiety disorders, and panic disorders
• Pharmaceutical composition for preventing or treating stress-induced dermatitis, atopic dermatitis, alopecia areata, and stress-induced acne, using ethyl acetoacetate as an active ingredient
• Fragrance composition for alleviating stress-induced diseases, comprising ethyl acetoacetate or a fragrance-acceptable salt as an active ingredient

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This invention was developed with support from the Ministry of Science and ICT for research into the collagen production regulation system in the dermis mediated by skin olfactory receptors.

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