Composition for anti-allergy, atopic dermatitis improvement, or skin regeneration containing nonane as an active ingredient

Composition for Improving Allergic Diseases and Atopic Dermatitis Containing Nonane as an Active Ingredient

This technology features a pharmaceutical composition for preventing and treating allergic diseases and atopic dermatitis, as well as compositions for improvement used in food, cosmetics, and fragrances, all containing nonane—a nine-carbon straight-chain alkane—or its salts as an active ingredient.

Atopic dermatitis has traditionally been treated with topical or systemic steroids, immunomodulators, and antihistamines, but these carry significant risks of side effects with long-term use. Furthermore, the condition is difficult to manage fundamentally due to its complex origins, including family history, diet, and skin barrier dysfunction.

This technology leverages the ability of nonane to suppress the expression of inflammatory cytokines such as IL-4, IL-13, TNF-α, IL-1β, IL-6, and IL-8, thereby calming both allergic reactions and atopic inflammation. It can be applied to a wide range of treatments for rhinitis, asthma, and hives, as well as moisturizing cosmetics for sensitive skin, allowing for simplified formulation design using a single small-molecule ingredient.

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Key Features:

• Pharmaceutical composition for the prevention or treatment of allergic diseases or atopic dermatitis containing nonane or a pharmaceutically acceptable salt as an active ingredient
• Nonane composition targeting conditions such as edema, hypersensitivity, allergic rhinitis, asthma, conjunctivitis, contact dermatitis, hives, pruritus, and allergies to insects, food, or drugs
• Pharmaceutical composition with nonane as an active ingredient that reduces the expression of IL-4, IL-13, TNF-α, IL-1β, IL-6, or IL-8
• Composition for the prevention or improvement of allergic diseases and atopic dermatitis in the form of functional food, cosmetics, or fragrances containing nonane or its salts as an active ingredient

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This invention was developed with support from the Ministry of Education, Science and Technology’s research project on identifying olfactory receptors that act as drug targets for anti-obesity phytochemicals.

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