Composition for the prevention, improvement, or treatment of skin damage

Composition for Improving Skin Damage Caused by Fine Dust Using Lovastatin-Based Compounds

This technology utilizes a lovastatin-based compound of Formula 1, commonly used as a hyperlipidemia treatment, or its salt as an active ingredient to restore dermal collagen synthesis impaired by fine dust. It is applicable to cosmetic, food, and pharmaceutical compositions.

Fine dust penetrates pores, causing acne, dryness, and itching, while accelerating skin aging through reduced elasticity and wrinkle formation. However, there has been a lack of proven active ingredients capable of restoring fine-dust-induced skin damage at the dermal level.

This technology repurposes existing statin drugs for dermatological use, inhibiting IL-24 overexpression and promoting collagen synthesis to improve skin elasticity, suppress wrinkles, and strengthen the skin barrier. By utilizing drugs with established safety profiles, it reduces development time and costs for anti-pollution cosmetics, inner beauty products, and skin damage treatments.

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Key Features:

• Cosmetic composition for promoting collagen synthesis comprising a compound represented by Formula 1 or a cosmetically acceptable salt thereof as an active ingredient
• Composition for enhancing skin barrier function comprising a compound of Formula 1, wherein R1 is C1-C5 alkyl and R2 and R3 are each independently C1-C2 alkyl, as an active ingredient
• Pharmaceutical composition for the prevention or treatment of skin aging, reduced skin elasticity, impaired skin barrier function, and wrinkle formation caused by fine dust
• Food composition comprising a compound of Formula 1 or a food-grade acceptable salt thereof as an active ingredient to improve collagen synthesis impaired by fine dust

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This invention was developed with support from the Ministry of Health and Welfare for the discovery and validation of anti-aging and whitening target substances through the investigation of senescence-associated secretory phenotype mechanisms induced by fine dust.

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