Method for culturing Polyporus tuberaster strains with anticancer activity

Anticancer composition for lung cancer based on Polyporus tuberaster strain culture broth

This technology is an anticancer composition for lung cancer that uses the Polyporus tuberaster strain, cultured in a medium containing dextrose and potato starch, or its culture broth as an active ingredient.

Conventional chemotherapy drugs often cause significant side effects such as hair loss, diarrhea, and weakened immunity by attacking healthy cells, while targeted therapies face challenges with drug resistance due to the rapid adaptation of cancer cells. Polyporus tuberaster has previously been known only for its use in treating hypercholesterolemia or as an ingredient in hair care products, with its potential as an anticancer agent remaining unexplored.

This technology enables the culture broth of the strain, grown in a specific medium, to exhibit anticancer activity by inhibiting MEK-ERK signaling in lung cancer cells, inducing apoptosis, and slowing cell cycle progression. It can be applied to the development of natural mushroom-derived lung cancer treatment candidates, anticancer adjuvants, and functional mushroom ingredients, allowing for the establishment of a natural product-based anticancer pipeline with fewer side effects.

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Key Features:

• Anticancer composition for lung cancer comprising, as an active ingredient, a Polyporus tuberaster strain cultured in a medium containing dextrose and potato starch, or its culture broth
• Anticancer composition where the strain culture broth inhibits p-ERK and p-MEK-1, and the culture broth includes the culture filtrate or its extract
• Polyporus tuberaster-derived anticancer composition that induces apoptosis in lung cancer cells and reduces the S-phase ratio in the cancer cell cycle
• Polyporus tuberaster-derived anticancer composition that inhibits cell proliferation by increasing p21 and p-Rb protein levels within cancer cells

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This invention was developed with support from the Ministry of Science and ICT for mitochondrial metabolism-based integrated aging control.

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