This technology utilizes methyl isobutyl carbinol or its salts as an active ingredient to alleviate acne, suppressing inflammation caused by acne bacteria at both the gene expression and protein levels. It includes applications in cosmetics, pharmaceuticals, and quasi-drugs, as well as methods for applying it to the skin by coating or soaking it onto packs, sheets, or patches.
Acne, which affects about 90% of adolescents and can persist into adulthood, begins as comedones and progresses to papules, pustules, and nodules as inflammation worsens. While retinoids for sebum control, alpha-hydroxy acids for exfoliation, and various antibacterial agents have been used, they often cause significant skin irritation, making consistent use difficult.
This technology provides multi-layered soothing of acne inflammation by having methyl isobutyl carbinol lower the expression of NF-κB, IL-6, IL-1β, and TNF-α genes while simultaneously reducing IL-8 protein production. It can be applied in various formulations such as creams, gels, mists, and powders, as well as in patch or sheet forms, allowing for the design of acne-soothing products tailored to specific areas and symptoms.
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