Composition for preventing, improving, or alleviating skin damage caused by anticancer drugs, containing tributyl acetylcitrate as an active ingredient

Functional composition containing tributyl acetylcitrate for alleviating skin toxicity caused by anticancer drugs

This technology is a composition for preventing and improving skin damage caused by anticancer drugs, utilizing the effect of reducing keratinocyte apoptosis and LDH activity when tributyl acetylcitrate is used in combination with chemotherapy. The scope of rights covers cosmetic compositions, as well as food, quasi-drug, and pharmaceutical compositions.

The number of cancer patients in Korea increased from approximately 100,000 in 1999 to over 250,000 in 2019, and with the 5-year relative survival rate exceeding 70%, more patients are undergoing long-term treatment. Chemotherapy has limitations, as it damages not only cancer cells but also normal cells such as blood, hair follicle, and mucosal cells, causing various side effects like hair loss and stomatitis.

This technology repurposes tributyl acetylcitrate, an additive with proven safety, as a skin-protective ingredient to mitigate epidermal cell damage caused by major cytotoxic anticancer drugs such as 5-fluorouracil, cyclophosphamide, and methotrexate. With minimal side effects even after prolonged use, it is suitable for repeated application throughout months-long chemotherapy cycles. It can be applied to body lotions, skin-protective creams, and inner-care foods for cancer patients, enabling the rapid development of products that alleviate skin discomfort during treatment using verified ingredients.

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Key Features:

• Cosmetic composition for preventing or improving skin damage caused by anticancer drugs, containing tributyl acetylcitrate or its cosmetically acceptable salts as an active ingredient
• Composition that reduces keratinocyte apoptosis and LDH activity by co-administering the active ingredient with one or more anticancer drugs, including 5-fluorouracil, cyclophosphamide, doxorubicin, methotrexate, docetaxel, or cisplatin
• Food composition for improving or alleviating skin damage containing tributyl acetylcitrate, which reduces keratinocyte apoptosis increased by anticancer drugs
• Quasi-drug and pharmaceutical compositions for preventing skin damage, containing tributyl acetylcitrate or its quasi-drug/pharmaceutically acceptable salts as an active ingredient

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