This technology features a whitening composition containing acetyl tributyl citrate or its salts as an active ingredient, which brightens skin tone by inhibiting both tyrosinase activity and melanin synthesis. The same ingredient can be formulated into cosmetic, pharmaceutical, and food compositions to prevent and improve conditions related to melanin overproduction.
While tyrosinase inhibitors like arbutin and kojic acid, along with vitamin C derivatives, have been standard whitening ingredients, they have faced issues such as limited efficacy or reported side effects like skin irritation. Since melanin overproduction is linked not only to hyperpigmentation like melasma and age spots but also to melanoma, there has been a need for safe and highly effective whitening ingredients.
This technology reduces the actual amount of pigment produced by simultaneously inhibiting tyrosinase, the starting point of the melanin production pathway, and subsequent pigment synthesis stages. It targets conditions such as melasma, freckles, lentigo, age spots, and post-inflammatory hyperpigmentation. It can be applied to functional whitening cosmetics, hyperpigmentation treatments, and inner beauty foods, allowing for the development of both topical and ingestible products using a single ingredient.
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