Composition for preventing hair loss or promoting hair growth containing decanal or its pharmaceutically acceptable salts as an active ingredient

Composition for Preventing Hair Loss and Promoting Hair Growth Using the Natural Compound Decanal

This technology utilizes decanal, an aldehyde-based natural compound found in plants such as lemon verbena, orange, and ginger, as an active ingredient in pharmaceutical, quasi-drug, cosmetic, and health functional food compositions designed to prevent hair loss and promote hair growth.

Finasteride is associated with side effects such as erectile dysfunction and decreased libido, while minoxidil can cause itching, rashes, and tachycardia. Despite hair loss being a chronic condition requiring long-term management, there has been a lack of safe, naturally derived treatment options suitable for extended use.

This technology promotes stable hair growth by increasing the expression of hair growth-related proteins such as Wnt10b, IGF1, and VEGF, while decreasing the expression of GSK3β and Axin. Its primary advantage is that it is a natural compound with a low risk of side effects, even with long-term use. It can be applied to anti-hair loss shampoos, hair tonics, eyelash serums, and topical hair loss treatments, meeting consumer demand for alternatives to synthetic drugs that avoid potential side effects.

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Key Features:

• Pharmaceutical composition for preventing hair loss or promoting hair growth containing decanal or its pharmaceutically acceptable salts as an active ingredient
• Action of increasing the expression of proteins selected from Wnt10b, FZD1, LRP5, IGF1, VEGF, HGF, and KGF, or decreasing the expression of GSK3β or Axin
• Pharmaceutical composition for preventing hair loss formulated as a topical skin application, such as a cream, gel, patch, spray, ointment, or lotion
• Cosmetic, quasi-drug, and health functional food compositions formulated as hair tonics, shampoos, eyelash growth serums, and pet shampoos

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This invention was developed with support from the Ministry of Education, Science and Technology’s research project on identifying olfactory receptors that act as drug targets for anti-obesity phytochemicals.

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