Composition for the prevention, improvement, or alleviation of chemotherapy-induced skin damage containing diethyl phthalate as an active ingredient

Composition for alleviating chemotherapy-induced skin damage using diethyl phthalate

This technology features a composition containing diethyl phthalate or its salts as an active ingredient, which reduces keratinocyte apoptosis and alleviates skin damage when used in conjunction with chemotherapy. It includes applications for cosmetics, food, quasi-drugs, pharmaceutical compositions, and methods for treating affected areas.

Keratinocytes form the skin barrier through intercellular lipids and differentiation factors like filaggrin, but chemotherapy increases the apoptosis of these cells, compromising barrier function. There has been a lack of safe, long-term solutions specifically targeting chemotherapy-induced skin dryness and damage.

This technology prevents and alleviates skin damage by reducing both keratinocyte apoptosis and LDH activity when used alongside chemotherapy. Since it utilizes a compound approved as a safe additive, it is ideal for moisturizing creams, patches, and specialized beauty lines for cancer patients, allowing for consistent use throughout the treatment period.

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Key Features:

• Cosmetic composition for preventing or improving chemotherapy-induced skin damage containing diethyl phthalate or its cosmetically acceptable salts as an active ingredient
• Composition configured to reduce keratinocyte apoptosis and LDH activity by co-administering the active ingredient with chemotherapy
• Food composition for improving skin damage, used in combination with chemotherapy agents selected from 5-fluorouracil, cyclophosphamide, methotrexate, docetaxel, and cisplatin
• Method for alleviating chemotherapy-induced skin damage comprising applying a composition containing diethyl phthalate to the affected area of a mammal

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