Composition for the prevention, improvement, or treatment of pigmentary disorders

Composition for Whitening and Improving Pigmentary Disorders Using 7DG Compounds

This technology features a composition containing 7-desacetoxy-6,7-dihydrogedunin (7DG) or its salts as an active ingredient to prevent, improve, and treat pigmentary disorders such as melasma, freckles, and age spots. It is formulated for use in pharmaceutical, food, cosmetic, and quasi-drug whitening products.

Existing whitening products and treatments for pigmentary disorders, such as hydroquinone, retinoids, and tyrosinase inhibitors, have been associated with side effects including mutations, toxicity, and ochronosis. Consequently, there has been a clear need for alternative whitening agents that offer high efficacy without these adverse effects.

This technology provides a safe whitening effect, as 7DG effectively inhibits tyrosinase activity and melanin synthesis without causing human toxicity. It can be applied to functional whitening cosmetics, treatments for pigmentary disorders, and inner beauty products, serving as a next-generation whitening ingredient that resolves concerns regarding the side effects of existing agents.

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Key Features:

• A pharmaceutical composition for the prevention or treatment of pigmentary disorders containing 7DG represented by Chemical Formula 1 or its pharmaceutically acceptable salts as an active ingredient
• A composition targeting pigmentary disorders such as melasma, freckles, age spots, blemishes, senile lentigo, solar lentigo, and post-inflammatory hyperpigmentation
• A cosmetic composition for whitening containing 7DG as an active ingredient to inhibit tyrosinase activity or melanin synthesis
• A whitening cosmetic or quasi-drug composition containing 7DG, available in various formulations such as creams, essences, lotions, masks, sunscreens, and foundations

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This invention was developed with support from the Ministry of Science and ICT for research on pigmentation mechanisms via the ATP/P2X7 axis and the development of pigmentation preventatives and treatments through the discovery of natural P2X7 inhibitors.

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