This technology features a pharmaceutical composition for the treatment and prevention of oxidative stress-related liver diseases, with Nectandrin B—a lignan compound derived from nutmeg—as its active ingredient. It also includes food compositions and health functional foods containing this ingredient to protect hepatocytes from oxidative stress.
If left untreated, liver disease can progress to fibrosis and liver cancer. Existing hepatoprotective agents like UDCA and silymarin have shown limited efficacy in preventing hepatocyte damage. While nutmeg has been used as a spice and herbal medicine, conventional organic solvent extraction also yields myristicin and elemicin, which are known to have hallucinogenic and carcinogenic effects, making it difficult to use as a liver-protective agent.
This technology minimizes harmful components while selectively isolating the active substance, Nectandrin B, to protect hepatocytes by inhibiting peroxide-induced cell death and reactive oxygen species production. With no cytotoxicity, it targets a wide range of liver conditions, including impaired liver function, hepatitis, fatty liver, cirrhosis, alcoholic liver disease, and liver cancer. It offers a safe, natural alternative to supplement existing treatments and can be applied to hepatoprotective pharmaceuticals, post-drinking liver health supplements, and fatty liver management products.
N/A
