This technology involves a pharmaceutical and health functional food composition for the prevention and treatment of ileus, using an extract of Humulus japonicus (Japanese hop)—a vine commonly found in fields and along roadsides—as an active ingredient. It is designed for use in both pharmaceuticals and food products, targeting not only ileus itself but also the inflammation caused by the condition.
Ileus is a condition where food and gas cannot pass through the intestines due to adhesions or temporary paralysis of intestinal motility following abdominal surgery. In patients undergoing laparotomy, this leads to significant pain and increases both hospital stays and medical costs. While rapid treatment is necessary due to the risk of complications like perforation or shock, there has been a limitation in that patients often require surgical intervention if medical treatment fails to improve the condition.
This technology utilizes a methanol extract of Humulus japonicus, which enhances gastrointestinal motility while reducing malondialdehyde (a marker of lipid peroxidation), increasing antioxidant factors such as SOD and glutathione, and lowering inflammatory cytokines like TNF-α and IL-1β. As a natural plant-derived material, it carries a low risk of side effects. It can be applied to gastrointestinal motility-improving drugs for postoperative recovery, digestive health supplements, and hospital meal supplements, helping to accelerate the recovery of intestinal function and reduce the burden of hospital stays and treatment costs.
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