This technology utilizes the Lacticaseibacillus rhamnosus IR06 strain, newly isolated and deposited as KFCC12014P, and a fermentate containing exopolysaccharides obtained by fermenting a substrate with this strain. The fermentate is used as an active ingredient in health functional foods for skin improvement, cosmetics, and pharmaceutical compositions for treating UV-induced dermatitis and photoaging.
UVB radiation generates excessive reactive oxygen species in the skin, damaging DNA and proteins and accelerating photoaging, such as wrinkles and loss of elasticity. Existing skin-improving ingredients like vitamins, collagen, and hyaluronic acid have poorly understood mechanisms, limited efficacy against complex inflammatory damage, and synthetic compounds raise safety concerns with long-term use, while evidence for the photoaging protection of polysaccharide materials remains insufficient.
This technology is designed to enhance antioxidant defense by scavenging ABTS radicals and reactive oxygen species and increasing Nrf2 and catalase expression, while reducing skin structural damage by inhibiting collagenase, elastase, tyrosinase, and hyaluronidase activity. It also protects the skin barrier by downregulating the NF-κB pathway and TNF-α, IL-1β, and IL-6 expression, and restoring loricrin, filaggrin, and involucrin expression in 3D artificial skin models. Applicable to UV-blocking functional cosmetics, inner beauty health foods, and photodermatitis treatments, it enables antioxidant, whitening, anti-wrinkle, and barrier-improving effects through a single probiotic-derived ingredient.
This invention was developed with support from the Ministry of Science and ICT for research into gut immunity-based functional skin health, inner beauty biomaterials, and their mechanisms.
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