This technology is a heparin-binding composition featuring oligoamine boronic acid (OAB) as an active ingredient, containing cationic amine groups and 1 to 3 phenylboronic acid groups. As a biodegradable synthetic receptor based on natural amino acids and 3-carboxyphenylboronic acid, it binds selectively and strongly to heparin under neutral conditions.
Heparin, used as an anticoagulant in cardiopulmonary bypass surgery, requires continuous blood concentration monitoring to prevent bleeding complications; however, conventional activated clotting time (ACT) measurements are limited by being indirect indicators. Furthermore, existing boronic acid-based receptors have had difficulty in practical blood applications due to low heparin-binding affinity at physiological neutral pH.
This technology utilizes both ion pairing of amine groups and boronic acid ester formation to achieve a heparin-binding affinity over 150 times higher than conventional boronic acid receptors. When combined with a pyrocatechol violet indicator, blood heparin concentration can be read directly through color changes. It can be applied to intraoperative anticoagulation monitoring kits and postoperative heparin neutralizers, simplifying hemostasis management and improving patient recovery.
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