Modified extracellular matrix-based hydrogel, method for preparing the same, and its uses

Modified Extracellular Matrix-Based Hydrogel for 3D Printing

This technology relates to a modified extracellular matrix-based hydrogel comprising a conjugate formed by a Michael addition reaction between an amine-functionalized extracellular matrix and denatured collagen, and its uses.

Conventional extracellular matrix hydrogels have weak mechanical properties, limiting their application in cell encapsulation and tissue engineering.

This technology provides enhanced mechanical properties and high cell viability through modification, and can be 3D printed as bioink for reconstructive transplantation of tissues such as artificial corneas.

‍

‍

Key Features:

• Michael addition conjugate of amine-functionalized extracellular matrix and denatured collagen
• Enhanced mechanical properties (viscoelasticity) compared to unmodified material
• Bioink with high cell viability
• 3D printing-based reconstruction of artificial tissues for transplantation