Recombinant microorganism producing 3-hydroxypropionic acid and a method for producing 3-hydroxypropionic acid using the same

Recombinant Microorganism Producing 3-Hydroxypropionic Acid

This technology involves a recombinant microorganism for producing 3-hydroxypropionic acid (3-HP), which includes mutations identified through an adaptive evolution strategy, and its production method.

There was a limitation of low productivity due to enzymatic activity imbalance and the accumulation of toxic intermediates in the 3-HP biosynthesis pathway.

This technology utilizes a recombinant microorganism with regulated intracellular metabolism to produce 3-HP from glycerol with high efficiency, making it applicable in related industrial sectors.

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Key Features:

• Recombinant microorganism including mutations identified through adaptive evolution strategy
• Introduction of GDHt·ALDH and cyaA·crp related genes
• 3-HP production from glycerol
• High production efficiency through intracellular metabolic regulation