A nanoprobe for intracellular pH measurement, and a method and device for measuring pH within a single cell using the same

Optical Fiber Nanowire-Based Nanoprobe for Intracellular pH Measurement

This technology is a nanoprobe that combines a pH-responsive fluorescent material with a nanowire at the tip of an optical fiber, and a method and device for measuring intracellular pH using this nanoprobe.

It has been challenging to accurately measure the pH inside a single cell without causing damage or contamination.

This technology accurately measures intracellular pH within a single cell by allowing the nanoprobe to pass through the cell membrane and organelles to measure fluorescent signals within the cytoplasm and nucleus.

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Key Features:

• pH-responsive fluorescent material coupled to a nanowire at the optical fiber tip
• Light incidence and fluorescence excitation via optical fiber
• Nanoprobe passing through cell membranes and organelles
• Intracellular pH measurement within a single cell through fluorescent signal analysis