RNA interference-inducing nucleic acid that inhibits off-target microRNA and its applications

RNA interference-inducing nucleic acid that selectively inhibits non-canonical targets of microRNA

This technology concerns an RNA interference-inducing nucleic acid that inhibits off-target genes of microRNA by modifying a portion of a specific microRNA's sequence.

Conventional microRNAs regulate both on-target and off-target interactions, which presented a limitation in selectively inducing only desired biological functions.

The RNAi-inducing nucleic acid of this technology can selectively enhance and induce functions that arise from off-target inhibition. This allows for its application in diverse fields, including pharmaceuticals and cosmetics, for regulating processes such as cell cycle, differentiation, migration, proliferation, and apoptosis.

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Key Features:

• RNA interference-inducing nucleic acid with a modified partial microRNA sequence
• Selectively inhibits off-target genes of microRNA
• Capable of regulating cell cycle, differentiation, dedifferentiation, migration, proliferation, and apoptosis
• Application in various fields, including pharmaceuticals and cosmetics