Hyaluronic acid-lipid derivatives, lipid nanoparticles containing them, and their uses

Hyaluronic acid-lipid derivative-based lipid nanoparticles for mRNA delivery

This technology concerns lipid nanoparticles containing hyaluronic acid-lipid derivatives and their uses as carriers for delivering mRNA, proteins, and drugs into the body.

Existing mRNA vaccine delivery systems have faced issues with chronic immunogenicity, low protein expression rates, and stability.

This technology consists of hyaluronic acid-lipid derivatives, ionizable lipids, cholesterol, and phosphatidylcholine, and exhibits excellent mucosal adhesiveness and permeability, thereby enhancing mRNA stability and delivery efficiency and enabling nasal and pulmonary delivery.

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Key Features:

• Lipid nanoparticles containing hyaluronic acid-lipid derivatives
• Combination of ionizable lipid, cholesterol, and phosphatidylcholine
• Excellent mucosal adhesiveness and permeability
• Enhanced mRNA stability and delivery efficiency