Insulin Receptor-Binding Aptamer Dimer and Its Uses

Insulin Receptor-Binding Aptamer Dimer with Minimized Side Effects

This technology relates to an aptamer dimer that binds to insulin receptors and its uses.

Long-term insulin therapy is associated with side effects, and the unclear molecular mechanism of insulin receptor activation has made safe alternative treatments challenging.

The aptamer dimer developed with this technology demonstrates a superior insulin receptor activation effect compared to monomers. It regulates pAKT without increasing pERK, thereby minimizing side effects and promoting glucose uptake, which leads to excellent efficacy in diabetes treatment.

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Key Features:

• Aptamer dimer binding to insulin receptors
• Enhanced receptor activation effect compared to monomers
• Selective signaling that regulates pAKT without increasing pERK
• Minimized side effects and promoted glucose uptake