Fluorescent probe compound for detecting protein aggregates and a fluorescent sensor comprising the compound for detecting protein aggregates

Fluorescent probe compound and sensor for selectively detecting endoplasmic reticulum protein aggregates

This technology relates to fluorescent probe compounds for detecting protein aggregates in cells, particularly in the endoplasmic reticulum, and fluorescent sensors comprising these compounds.

While protein aggregation is associated with various diseases, there has been a lack of methods for selectively and reliably detecting aggregates within the endoplasmic reticulum.

This technology can contribute to research into related diseases and the development of therapeutic methods by effectively detecting protein aggregates induced by endoplasmic reticulum stress, using a fluorescent probe that selectively acts on the endoplasmic reticulum.

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Key Features:

• Fluorescent probe compound for detecting endoplasmic reticulum protein aggregates
• ER-selective probe synthesized using copper-catalyzed click reaction
• Effective detection of protein aggregates induced by endoplasmic reticulum stress
• Fluorescent sensor applicable for research and therapeutic development of protein aggregation-related diseases