Cell-like Liposome

Liposome that improves drug delivery efficiency by introducing extracellular matrix (ECM) and cytoskeleton

This technology is about cell-like liposomes. Existing liposomes have limitations in drug delivery due to instability in the body and low delivery efficiency, but it provides cell-like liposomes and an improved drug delivery system using them.

The developed liposome contains an extracellular matrix (ECM) and cytoskeleton in a phospholipid membrane composed of anionic lipids and neutral lipids, so it has strength and flexibility similar to real cells and can dramatically increase drug delivery efficiency by securing high stability and affinity in vivo.

This technology overcomes the shortcomings of existing drug delivery systems and builds a next-generation drug delivery system that is biocompatible and stable, and cell-like liposomes have the characteristics of improved strength and flexibility.

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Key Features:

• Manufacturing a phospholipid membrane composed of anionic lipids, neutral lipids, and ion-permeable carriers
• Introducing a single-molecule cytoskeleton (e.g., G-actin) into the phospholipid membrane through methods such as application of electricity
• Binding the extracellular matrix to the liposome surface through ionic bonding with anionic lipids, and stably coating the surface through self-assembly polymerization reaction
• Thanks to a cell-like structure, it is resistant to changes in the external environment Has resistance

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This technology was developed through support from the National Research Foundation of Korea's artificial cell structure and function simulation research project.

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