Au nano-dot decorated hollow silica nanoparticle for chemo-photothermal therapy and method for preparing the same

Surfactant-free gold nanodot hollow silica nanoparticles

This technology concerns hollow silica nanoparticles containing gold nanodots, which are nanocarriers for the dual treatment of chemotherapy and photothermal therapy.

Existing nanocarriers for cancer treatment had problems with drug leakage and toxicity due to surfactants. This technology presents gold nanodot-containing hollow silica nanoparticles and a method for their preparation that overcome these limitations. These nanoparticles are a dual therapeutic agent that performs both chemotherapy and photothermal treatment at the same time. They are easily manufactured in a single process and do not use surfactants harmful to the human body, making them highly biocompatible.

In particular, the photothermal effect is amplified through dopamine and hyaluronic acid coating, side effects are minimized by precisely controlling drug release depending on pH, and the tumor-targeting ability of hyaluronic acid is utilized to selectively deliver the drug to cancer cells, maximizing the synergy effect of combination treatment

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Key Features:

• An in-situ synthesis method that simultaneously forms the structure of hollow silica nanoparticles and the formation of gold nanodots that produce photothermal effects in one process.
• Forms a hollow structure with an empty interior by etching silica nanoparticles using polyethyleneimine (PEI) and a gold precursor. This complex binds to silica to promote efficient etching and gold nano-dot formation.

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This technology was developed through the National Research Foundation of Korea's neural stem cell differentiation induction research project using multi-functional smart nanotransmitters.

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